Hydrazides--a novel type of derivatives of polyene macrolide antifungal antibiotics.

properties ofpolyene macrolides wehave established the structure-activity relationship among the derivatives of amphotericin B, the polyene antibiotic most commonly used in clinical practice11}. It has been shown in these studies that the improvement of selective toxicity is related to the absence of a free carboxyl group in the modified antibiotic molecule. Wehave also demonstrated that water solubility of amphotericin B derivatives occurs only with net charged molecules. In the present paper we report the novel group of polyene macrolide derivatives fulfiling the above requirements for improved selective toxicity and water solubility. These are polyene macrolide